AustralieFrV1, Main, Exploration, bibRecord, 007758

Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT

Identifieur interne : 007758 ( Main/Exploration ); précédent : 007757; suivant : 007759

Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT

Auteurs : Andrée-Laure Herr [France] ; Nabil Kabbara [France] ; Carmem M. S. Bonfim [Brésil] ; Pierre Teira [France] ; Franco Locatelli [Italie] ; Karin Tiedemann [Australie] ; Arjan Lankester [Pays-Bas] ; Jean-Pierre Jouet [France] ; Chiara Messina [Italie] ; Yves Bertrand [France] ; Cristina Díaz De Heredia [Espagne] ; Christina Peters [Autriche] ; Wagnara Chaves [France] ; Samir K. Nabhan [Brésil] ; Irina Ionescu [France] ; Eliane Gluckman [France] ; Vanderson Rocha [France]

Source :

Blood [ 0006-4971 ] ; 2010.

RBID : Pascal:10-0451309

Descripteurs français

Pascal (Inist)
- Homogreffe, Long terme, Etude longitudinale, Tumeur maligne, Pronostic, Histocompatibilité, Cellule souche, Cellule hématopoïétique, Cordon ombilical, Cellule sanguine, Homme, Malignité, Hématologie, EBMT.
Wicri :
- topic : Cellule souche, Homme.

English descriptors

KwdEn :
- Blood cell, European group for blood and marrow transplantation, Follow up study, Hematology, Hematopoietic cell, Histocompatibility, Homograft, Human, Long term, Malignancy, Malignant tumor, Prognosis, Stem cell, Umbilical cord.

Abstract

We analyzed risk factors influencing outcomes after related (R) human leukocyte antigen-identical cord blood transplantation (CBT) for 147 patients with malignancies reported to Eurocord-European Group for Blood and Marrow Transplantation. CBT has been performed since 1990; median follow-up was 6.7 years. Median patient age was !i years. Acute leukemia was the most frequent diagnosis (74%). At CBT, 40 patients had early, 70 intermediate, and 37 advanced disease. CB grafts contained a median of 4.1 x 10⁷/kg total nucleated cells (TNCs) after thawing. The cumulative incidence (CI) of neutrophil recovery was 90% at day +60. CIs of acute and chronic graft-versus-host disease (GVHD) were 12% and 10% at 2 years, respectively. At 5 years, CIs of nonrelapse mortality and relapse were 9% and 47%, respectively; the probability of disease-free survival (DFS) and overall survival were 44% and 55%, respectively. Among other factors, higher TNCs infused was associated with rapid neutrophil recovery and improved DFS. The use of methotrexate as GVHD prophylaxis decreased the CI of engraftment. Patients without advanced disease had improved DFS. These results support banking and use of CB units for RCBT. Cell dose, GVHD prophylaxis not including methotrexate, and disease status are important factors for outcomes after RCBT.

Affiliations:

Australie, Autriche, Brésil, Espagne, France, Italie, Pays-Bas
Auvergne-Rhône-Alpes, Catalogne, Hauts-de-France, Hollande-Méridionale, Nord-Pas-de-Calais, Rhône-Alpes, Victoria (État), Vienne (Autriche), Île-de-France
Barcelone, Leyde, Lille, Lyon, Melbourne, Paris, Vienne (Autriche)

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002330
to stream PascalFrancis, to step Curation: 003C64
to stream PascalFrancis, to step Checkpoint: 002287
to stream Main, to step Merge: 007D55
to stream Main, to step Curation: 007758

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT</title>
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<s3>ITA</s3>
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<author><name sortKey="Bertrand, Yves" sort="Bertrand, Yves" uniqKey="Bertrand Y" first="Yves" last="Bertrand">Yves Bertrand</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="De Heredia, Cristina Diaz" sort="De Heredia, Cristina Diaz" uniqKey="De Heredia C" first="Cristina Díaz" last="De Heredia">Cristina Díaz De Heredia</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Hospital Vall d'Hebron</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
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<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Paediatric Diseases Working Party-EBMT, St-Anna Kinderspital</s1>
<s2>Vienna</s2>
<s3>AUT</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chaves, Wagnara" sort="Chaves, Wagnara" uniqKey="Chaves W" first="Wagnara" last="Chaves">Wagnara Chaves</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Eurocord, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nabhan, Samir K" sort="Nabhan, Samir K" uniqKey="Nabhan S" first="Samir K." last="Nabhan">Samir K. Nabhan</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Hospital de Clinicas</s1>
<s2>Curitiba</s2>
<s3>BRA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Brésil</country>
<wicri:noRegion>Hospital de Clinicas</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ionescu, Irina" sort="Ionescu, Irina" uniqKey="Ionescu I" first="Irina" last="Ionescu">Irina Ionescu</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Eurocord, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Eurocord, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Eurocord, Hôpital Saint-Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Blood</title>
<title level="j" type="abbreviated">Blood</title>
<idno type="ISSN">0006-4971</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood cell</term>
<term>European group for blood and marrow transplantation</term>
<term>Follow up study</term>
<term>Hematology</term>
<term>Hematopoietic cell</term>
<term>Histocompatibility</term>
<term>Homograft</term>
<term>Human</term>
<term>Long term</term>
<term>Malignancy</term>
<term>Malignant tumor</term>
<term>Prognosis</term>
<term>Stem cell</term>
<term>Umbilical cord</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Homogreffe</term>
<term>Long terme</term>
<term>Etude longitudinale</term>
<term>Tumeur maligne</term>
<term>Pronostic</term>
<term>Histocompatibilité</term>
<term>Cellule souche</term>
<term>Cellule hématopoïétique</term>
<term>Cordon ombilical</term>
<term>Cellule sanguine</term>
<term>Homme</term>
<term>Malignité</term>
<term>Hématologie</term>
<term>EBMT</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We analyzed risk factors influencing outcomes after related (R) human leukocyte antigen-identical cord blood transplantation (CBT) for 147 patients with malignancies reported to Eurocord-European Group for Blood and Marrow Transplantation. CBT has been performed since 1990; median follow-up was 6.7 years. Median patient age was !i years. Acute leukemia was the most frequent diagnosis (74%). At CBT, 40 patients had early, 70 intermediate, and 37 advanced disease. CB grafts contained a median of 4.1 x 10<sup>7</sup>
/kg total nucleated cells (TNCs) after thawing. The cumulative incidence (CI) of neutrophil recovery was 90% at day +60. CIs of acute and chronic graft-versus-host disease (GVHD) were 12% and 10% at 2 years, respectively. At 5 years, CIs of nonrelapse mortality and relapse were 9% and 47%, respectively; the probability of disease-free survival (DFS) and overall survival were 44% and 55%, respectively. Among other factors, higher TNCs infused was associated with rapid neutrophil recovery and improved DFS. The use of methotrexate as GVHD prophylaxis decreased the CI of engraftment. Patients without advanced disease had improved DFS. These results support banking and use of CB units for RCBT. Cell dose, GVHD prophylaxis not including methotrexate, and disease status are important factors for outcomes after RCBT.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>Brésil</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Catalogne</li>
<li>Hauts-de-France</li>
<li>Hollande-Méridionale</li>
<li>Nord-Pas-de-Calais</li>
<li>Rhône-Alpes</li>
<li>Victoria (État)</li>
<li>Vienne (Autriche)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Leyde</li>
<li>Lille</li>
<li>Lyon</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Vienne (Autriche)</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Herr, Andree Laure" sort="Herr, Andree Laure" uniqKey="Herr A" first="Andrée-Laure" last="Herr">Andrée-Laure Herr</name>
</region>
<name sortKey="Bertrand, Yves" sort="Bertrand, Yves" uniqKey="Bertrand Y" first="Yves" last="Bertrand">Yves Bertrand</name>
<name sortKey="Chaves, Wagnara" sort="Chaves, Wagnara" uniqKey="Chaves W" first="Wagnara" last="Chaves">Wagnara Chaves</name>
<name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<name sortKey="Ionescu, Irina" sort="Ionescu, Irina" uniqKey="Ionescu I" first="Irina" last="Ionescu">Irina Ionescu</name>
<name sortKey="Jouet, Jean Pierre" sort="Jouet, Jean Pierre" uniqKey="Jouet J" first="Jean-Pierre" last="Jouet">Jean-Pierre Jouet</name>
<name sortKey="Kabbara, Nabil" sort="Kabbara, Nabil" uniqKey="Kabbara N" first="Nabil" last="Kabbara">Nabil Kabbara</name>
<name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<name sortKey="Teira, Pierre" sort="Teira, Pierre" uniqKey="Teira P" first="Pierre" last="Teira">Pierre Teira</name>
</country>
<country name="Brésil"><noRegion><name sortKey="Bonfim, Carmem M S" sort="Bonfim, Carmem M S" uniqKey="Bonfim C" first="Carmem M. S." last="Bonfim">Carmem M. S. Bonfim</name>
</noRegion>
<name sortKey="Nabhan, Samir K" sort="Nabhan, Samir K" uniqKey="Nabhan S" first="Samir K." last="Nabhan">Samir K. Nabhan</name>
</country>
<country name="Italie"><noRegion><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name>
</noRegion>
<name sortKey="Messina, Chiara" sort="Messina, Chiara" uniqKey="Messina C" first="Chiara" last="Messina">Chiara Messina</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Tiedemann, Karin" sort="Tiedemann, Karin" uniqKey="Tiedemann K" first="Karin" last="Tiedemann">Karin Tiedemann</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Lankester, Arjan" sort="Lankester, Arjan" uniqKey="Lankester A" first="Arjan" last="Lankester">Arjan Lankester</name>
</region>
</country>
<country name="Espagne"><region name="Catalogne"><name sortKey="De Heredia, Cristina Diaz" sort="De Heredia, Cristina Diaz" uniqKey="De Heredia C" first="Cristina Díaz" last="De Heredia">Cristina Díaz De Heredia</name>
</region>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT

Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT

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